Tilmvot 300 for injection 100 ml
 
Labels:
Veterinary medicine for use in cattle, for the treatment of respiratory diseases in cattle caused by Pasteurella multocida and by other organisms sensitive to telmycosin. For the treatment of rot in sheep.
Tilmvot for injection is a sterilized solution containing tilmicosin at a concentration of 300 mg/ml. Telmicosin is a semi-synthetic antibiotic from the macrolide group.
 
Toxicology:
The heart was exposed to the toxicity of the product in laboratory animals and in farm animals that received tilmicosin orally or parenterally. The main effects on the heart are increased heart rate (tachycardia) and reduced contraction of the heart muscle (negative inotropic effect). The toxic effects on the cardiovascular system may be due to the blocking of calcium channels. When administered by subcutaneous injection, the acute median lethal dose of tilmicosin in mice is 97 mg/kg and in rats 185 mg/kg of body weight.
In dogs, intravenous calcium balanced the tachycardia and negative inotropic effect caused by tilmicosin and restored arterial pulse pressure to normal. Dobutamine partially offset the negative inotropic effect caused in dogs by tilmicosin. Beta-adrenergic antagonists, such as propranolol, exacerbated the negative inotropic effect of tilmicosin in dogs. In monkeys, a single intramuscular dose of 10 mg/kg did not cause any signs of toxicity. A single dose of 20 mg/kg caused vomiting and a 30 mg/kg dose caused the death of the only monkey tested.
Beta-adrenergic antagonists, such as propranolol, exacerbated the negative inotropic effect of tilmicosin in dogs and should therefore not be used. Adrenaline has made tilmicosin lethal in pigs and therefore should not be used. In pigs, intramuscular injection of a dose of 10 mg/kg increased the respiratory rate and induced vomiting and convulsions. A dose of 20 mg/kg caused the death of 3 out of 4 pigs and a dose of 30 mg/kg caused the death of all 4 pigs tested. Intravenous injection of 4.5 and 5.6 mg/kg followed by 1 mL of intravenous adrenaline 2 to 6 times caused the death of all pigs receiving the injections. All pigs receiving 4.5 and 5.6 mg/kg "c Intravenous without adrenaline, they survived. These results indicate that the administration of adrenaline intravenously may be a contraindication. In cattle, doses of 10 and 20 mg/kg of body weight Tilmvot given by subcutaneous injection, each dose three times 24 hours One of the other, did not cause death at all. Edema was seen at the injection site. A dose of 150 mg/kg injected subcutaneously every 72 hours caused deaths and marked edema at the injection site, and a postmortem examination revealed minimal necrosis of the myocardium.
 
Instructions for use:
Inject under the skin only in the back half of the neck. Cattle: for the treatment of respiratory diseases, one dose should be given under the skin at 10 mg/kg of body weight (1 ml per 30 kg). Do not inject more than 15 ml at the same injection point. Sheep: for the treatment of caries rot, one dose should be given under the skin at a height of 5 mg/kg of body weight (1 ml per 60 kg). Do not give For patches weighing less than 15 kg. Make sure the animal is properly restrained to reduce the risk of accidental self-injection. If there is no improvement within 48 hours, re-diagnosis should be performed.
 
Caution:
 The safety of tilmicosin has not yet been established in pregnant cows or animals used for breeding purposes. Intramuscular injection will cause a local reaction that may cause tingling.
 
Contraindications:
 Intravenous injection in cattle can cause death. The injection has been proven to kill pigs, primates, goats and plaices whose body weight is less than 15 kg. The injection can also kill horses.
 
Waiting period:
 Meat: Do not slaughter animals that provide meat and internal organs for human consumption during the following time periods: cattle - 28 days from the last treatment, sheep - 42 days from the last treatment.
Milk: Milk intended for sale for human consumption must be discarded during the treatment period and at least for 35 days after the last treatment.
 
warning:
Ingestion of the product may be harmful. Causes skin and eye irritation. Very toxic to fish and aquatic animals. Very harmful to terrestrial vertebrates. Wear protective gloves. Clothes that have been exposed to the product should be removed and washed before they are reused. Hands and skin exposed to the product should be thoroughly washed after use. Do not eat, drink or smoke while using the product. If the product touches the skin: wash with plenty of soap and water. If skin irritation occurs, seek medical attention. If the product touches the eyes: rinse carefully with water for a few minutes. Contact lenses should be removed, if used and easy to remove. Continue to wash. If irritation persists, seek medical attention. If a medical opinion is needed, the container or label must be shown to the doctor. Injecting the product into humans has caused deaths in the past. Care should be taken to avoid accidental self-injection. Do not use Tillmoot while you are alone. Do not inject with electric auto-injectors. Do not carry a syringe filled with Tilmut with a needle attached to the end, unless you intend to fill the syringe or inject the product into an animal. Except in these circumstances, the needle should be removed from the syringe. If the substance has been injected into a person, a doctor should be consulted immediately and ice or a cold pack should be placed on the injection site. Call the National Poison Center at Rambam Hospital at 04-8541900 if you are exposed to the product or if you feel unwell or in case of accidental self-injection. In case of evacuation for medical help, show this label to the doctor. Avoid spillage in the environment. Collect the amount spilled.
 
Note to the doctor:
The cardiovascular system is exposed to the product's toxicity (the cause of this may be the blocking of the calcium channels), so its function must be carefully monitored. In dogs, intravenous calcium balanced the tachycardia and negative inotropic effect (reduced myocardial contractility) caused by tilmicosin. Dobutamine partially balanced the negative inotropic effect in dogs. Beta-adrenergic antagonists, such as propranolol, exacerbated the negative inotropic effect of tilmicosin in dogs and should therefore not be used.
Adrenaline has made tilmicosin lethal in pigs and therefore should not be used. Telmicosin remains in the tissues for several days. The condition of the cardiovascular system must be monitored and appropriate supportive care given. Must be stored at a temperature lower than 25 degrees Celsius in a place protected from sunlight. The product must be stored in a locked place. Must be used within 28 days of opening.
 
Dairy cows are not allowed