Luteosyl solution for veterinary injection
 
composition:
D-cloprostenol (as D-cloprostenol sodium 75ug/ml

Inactive ingredients:
Ethanol, Citric Acid, Chlorocresol, Sodium Hydroxide, Water for Injection
 
Labels:
Luteosil is prescribed for the treatment of accelerating the reproductive cycle in cows, pigs and mares.
Luteosil is based on the active substance dextrorotatory cloprostanol, which is a synthetic analog of prostaglandin alpha (F2α), in the form of a ready-to-inject solution. Luteosil contains the D enantiomer which is the luteolytic biologically active substance of cloprostanol.
The active ingredient in Luteosyl - (+) Cloprostenol is 3.5 times more active than the racemic mixture of Cloprostenol, so it is possible to use smaller and more effective amounts. In the luteinitizing phase of the sexual cycle, luteosyl in the ovary causes a decrease in LM receptors - and also results in the withdrawal of the corpus luteum and at the same time a sharp decrease in the amount of progesterone. As a result, the rest of the marrow secretes FSH, and this results in the maturation of the follicle for estrus and ovulation.
 
Labels:
• Induction of estrus and synchronization of estrus in cows and horses.
• Induction of litter in cows, mares and pigs.
• Lack of estrus after calving - dysfunction of the ovaries in the presence of yellow body persistent C.I
• Luteal cysts.
•    pregnancy termination.
• Fetal mummification
• Pyometra.
• Delayed in the involution of the uterus, Post Puerperal Metropathy
• Combined treatment of cysts (follicular) 10-14 days after administration. GnRH or HCG -
 
Dosage and form of administration: injection into the muscle at a dose according to the instructions:
Cows: 2 ml containing 0.15 mg active substance.
• To induce oestrus and also in cows with a quiet or weak demand. After checking the presence of the corpus luteum (6-18 days per cycle), Luteosil should be given, usually you can see an increase in temperature 48-60 hours after the injection, you should inject 72-96 hours after the treatment. If there is no estrus, the treatment should be repeated 11 days later The first treatment.
• To induce litter. Luteosil should be given after the 270th day of pregnancy, according to the medical opinion. Spawning should begin 30-60 hours after treatment.
• Synchronization of estrus. Luteosil should be given twice with an interval of 11 days.
Sow 72-96 hours after the second dose.
• Ovarian dysfunction - after verifying the presence of a yellow body, Luteosil should be given and inseminated - in the first heat after treatment. If there is no estrus, a genital examination should be performed and an additional dose given, 11 days after the first dose. Sow 72-96 hours after treatment.
• Endometritis, pyometra: one Luteosil dose should be given. If necessary, the treatment can be repeated at 10-day intervals.
• Termination of pregnancy: Luteosil must be given in the first half of pregnancy -
• Fetal mummification: One Luteosil dose should be given. The fetus will be expelled in 3-4 days
• Delayed in the involution of the uterus - Post Puerperal Metropathy,
Retarded Uterine Involution. One Luteosil dose should be given. If necessary, repeat the treatment once or twice at a dose of 1 ml and at an interval of 24 hours.
• Combined treatment for Follicular Cysts: Luteosil should be given 10-14 days after giving GnRh or HCG. When you see a positive reaction of the ovary.
Mares: 1 ml Luteosil (0.075 mg active substance).
• To induce estrus: Luteosil should be given, preferably after diagnosing the presence of a corpus luteum (by a blood progesterone test).
• For the induction of calving: Luteosil can be given 320 days after the beginning of pregnancy and taking into account the medical considerations.
• To speed up the calving: calving starts a few hours after the injection.
• Insemination planning (foaling) - Luteosil must be given twice 14 days apart. The stud (insemination) on days 19 and 21 after the first treatment even if there are no signs of heat.
• Prolonged diestrous interruption: Luteosil must be given to induce estrus - estrus will appear 2-8 days after the treatment.
• Simulated termination of pregnancy: Luteosil should be given to regulate normal ovarian activity.
• Lack of estrus during breastfeeding: after checking the cyclic activity, Luteosil should be given from 20-22 days after calving and thus determine the date of estrus and ovulation.
• Fetal death: Luteosil should be given immediately after verifying the presence of a corpus luteum (with the help of a blood progesterone level test) and insemination at the beginning of estrus.
Pigs:
• To induce calving: 1 ml of Luteosil starting on day 112 of pregnancy. In 70% of cases, calving will take place within 19-36 hours.

Warnings:
• If you know of a hypersensitivity to the substance, you should avoid handling this substance.
• Do not treat BH during pregnancy unless an abortion is desired.
• Do not treat mares suffering from diseases of the respiratory tract and digestive system.
• Since there is a delay in the production of NSAID prostenalgidines, Luteosil should not be treated in patients treated with endonenes.
• Luteosil may be absorbed through the skin. This should be avoided and for this purpose gloves should be used and also be careful of self-injection.
• Care must be taken with the Luteosil treatment, especially for women of childbearing age. If skin contact occurs, wash with soap and water.
• Can cause bronchospasm in people, if there are breathing difficulties as a result of breathing the substance PGF2 or injecting it, the doctor should be informed immediately.
• The treatment must be given under the supervision of a veterinarian.
 
Contraindications:
 The use of this preparation is prohibited in pregnant animals - unless abortion or littering is desired.
 
Side Effects:
No side effects are reported.

Drug interactions:
Animals should not be used in combination with non-steroidal anti-inflammatory drugs, since they inhibit the internal production of prostaglandins. It is possible to accelerate the activity of products that cause litters when used together with the product.
 
Waiting period:
• Cows before slaughter - 0 days, milk 0 days.
• Pigs before slaughter - do not use the product for food, for 24 hours after the treatment.
 
Storage and use instructions:
• Store in a cool, dry place, protected from light.
• Keep out of reach of children.
• In case of contact, wash with soapy water
 
packing:
Lotsoil, marketed in 20 ml packages.